The Need for Effective Adjuvant Therapy in Uterine Leiomyosarcoma: A Single-centre Experience
نویسندگان
چکیده
Objective To evaluate the efficacy of adjuvant chemotherapy (ACTx) in completely resected uterine leiomyosarcoma (ULMS) terms survival outcomes. Study design Descriptive study. Place and duration study Department Medical Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training Research Hospital, Ankara, Turkey from February 2009 to November 2019. Methodology Patients older than 18 years, who underwent complete surgical resection with a diagnosis non-metastatic ULMS were evaluated retrospectively. The patients divided into two groups: received ACTx (group I) only treatment II). Both groups compared main patient tumour characteristics, relapse rates, relapse-free (RFS) overall (OS). Results Forty-five median age 52.1 years (IQR, 45.8-58.2) included Group I consisted 26 (57.8%) group II 19 (42.2%) patients. Median RFS was 43.8 months (95% CI, 7.4-80.2) OS 81.3 39.4-123.1) for all (N = 45). 27.1 6.8-47.4) (n 26) 11.8-75.8) 19) (p 0.985). 85.6 38.3-132.9) 81.2 62.1-100.4) 0.699). Conclusion: There no benefit ULMSs, accordance literature data. is need prospective randomised clinical trials evaluating role ULMSs. Key Words: Uterine leiomyosarcoma, Complete resection, Adjuvant chemotherapy, Relapse, RFS, OS.
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ژورنال
عنوان ژورنال: JCPSP. Journal of the College of Physicians & Surgeons Pakistan
سال: 2021
ISSN: ['1022-386X', '1681-7168']
DOI: https://doi.org/10.29271/jcpsp.2021.08.926